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|Appearance:||White Solid||Usage:||Antihistaminic, Antiemetic, CNS Depressant|
Pharmaceutical Intermediate Promethazine Hydrochloride CAS 58-33-3
Phenothiazine hydrochloride;Promethazine Hcl
For the treatment of allergic disorders,and nausea/vomiting.
Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects.It also reduces motion sickness and has antiemetic and anticholinergic properties(via its action on the dopamine receptor D2). In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under many brand names. Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine
Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol.
|Description||White crystalline powder||
White crystalline powder
|Loss on drying||≤0.5ml||
|Residue on ignition||Not more than 0.2%||
|Iron||Not more than 0.005%||
|Heavy metals||Not more than 0.001%||
|Related substances||Total: Not more than 1.0%
Individual: Not more than 0.5%
|E-isomer||Not more than 0.3%||
Organic volatile impurities
Conform with USP30
Promethazine is used to prevent and treat nausea and vomiting related to certain conditions(such as before/after surgery, motion sickness). It is also used to treat allergy symptoms such as rash, itching, and runny nose. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. It may also be used for a short time to treat a runny nose due to the common cold.
Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.
(1)Antihistaminic, antiemetic,CNS depressant.
(3)With aminophylline in the treatment of asthma.
(4)For the treatment of allergic disorders, and nausea/vomiting.
(5)Dubbed hibernation and injection for artificial hibernation.
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