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|Melting Point:||254-260 °C||Usage:||Anti-Inflammatory|
Pharmaceutical Naphazoline Hydrochloride For Vasoconstrictor CAS 550-99-2
Clera; Niazol; Coldan; Naphcon; Rhinoperd; Rhinantin; Stricylon; Strictylon; Naphconforte; Sanorin-spofa;
White Crystalline Powder
This product is α-receptor agonist, a contraction of nasal blood vessels, reducing blood vessel exudate, reduce nasal congestion swelling. Clinically used to treat colds and allergic rhinitis, inflammatory nasal congestion, acute and chronic rhinitis.
Naphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops.
Naphazoline is a decongestant used to relieve redness, puffiness, and itchy/watering eyes due to colds, allergies, or eye irritations (smog, swimming, or wearing contact lenses). It is known as a sympathomimetic (alpha receptor agonist) that works in the eye to decrease congestion.
Some brands of naphazoline eye drops also contain other ingredients. Lubricants (such as glycerin, hypromellose, or polyethylene glycol 300) help protect the eyes from more irritation. Zinc sulfate, an astringent, helps reduce redness and irritation.
|Appearance||White crystalline powder||
|Loss on drying||0.50% Max||
|Residue on ignition||0.20% max||
|Total impurities||not more than 2.0%||
|Alcohol||Not more than 300 ppm||
Naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology , it is a adrenomimetic drug , it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system, by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. Clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. Local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. It can not be taken orally. Dropping excess liquid or high concentrations can cause poisoning. Care should be taken, especially in children. Infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. The interval time of dropping , is preferably not less than 4 to 6 hours.
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